The Interactive Effect of Aerobic-Resistance Training and Estrogen Therapy on Metabolic Syndrome Indices and Omentin-1

Introduction: obesity and visceral fat accumulation after menopause are associated with insulin resistance and cardiovascular diseases. we investigated the interactive effect of aerobic-resistance training and estrogen replacement therapy on visceral fat, omentin-1 and homa-ir in ovariectomized rats.materials and methods: fifty female wistar rats were ovariectomized (ovx) and divided into 5 groups (n=10 rats per group): ovx+sedentary (sedentary), aerobic-resistance training (ovx+exe), aerobic-resistance training+estrogen replacement therapy (ovx+exe+est), estrogen replacement therapy (ovx+est) and sesame oil (ovx+oil). the exercise consisted of 8-week aerobic-resistance training (20 m/min, 3 days/week, 60 min/day, 10% slope, load; 3% body weight).17b-estradiol valerate (30 µg/kg bw; in 0.2 ml sesame oil) were injected subcutaneously, three days a week during 8 weeks; and the ovx+est+est received both exercise protocol and estradiol as previous groups. obtained data were analyzed by anova and post hoc tukey test.results: omentin-1showed significant increase in ovx+exe compared to ovx+exe+est and ovx+est (p < 0.05). homa-ir and visceral fat was decreased in ovx+exe, ovx+exe+est compared to sedentary (p < 0.05).conclusion: eight-week aerobic-resistance training, 17-b estradiol replacement and co-treatment of exercise+estrogen successfully decreased visceral fat and insulin resistance probably via elevation in omentin-1 in ovaryectomized rats. regarding the risk of hormone replacement therapy this study suggests that 2- month aerobic-resistance training is more effective in treating metabolic syndrome, rather than estrogen replacement therapy.