the therapeutic effects of erythropoietin and carbamylated erythropoietin derivatives in neurological and other disorders

Erythropoietin (epo) has been considered in several studies as a significant factor in the development of erythroid cells, the inhibition of neuronal cell death, and neurogenesis. fortunately, a modified version of epo called carbamylated erythropoietin (cepo) possesses tissue-protective properties without eliciting erythropoietic effects. cepo is a derivative of epo that results in an alpha-amino derivative group with less biological hematopoiesis than epo. in neurological diseases, cepo and its carbamylated erythropoietin fc fusion protein (cepo-fc) has been shown to play a better role than epo. in this study, the effects of epo and its derivatives on neurological diseases and their role in treatment have been reviewed.