the effect of calcium channels blockade on slow-wave distribution in the electrophysiological model of human gastric wall smooth muscle cells

Introduction: two of the most important ion channels in the smooth muscle membrane are l-type and t-type calcium channels. l-type calcium channels are responsible for smooth muscle contraction, while t-type calcium channels are involved in cell membrane depolarization.methods: in this study, a model consisting of 1200 cells was used to simulate the smooth muscle of the gastric wall. the paper explores the effects of blocking 10%, 50%, 90%, and 100% of l-type and t-type calcium channels on the spatiotemporal wavefront propagation in human gastric wall smooth muscle cells, simulated separately.results: the results showed that complete blockage had the most significant effect on the slow-wave. blockage of the l-type calcium channel led to a reduction of -3.4% and -0.8% in the membrane potential during the spike and plateau phases, respectively. the t-type calcium channel reduced the spike and resting membrane potential by -1.8% and -0.9%, respectively. in addition, the l-type calcium channel exhibited a greater impact on reducing muscle contraction compared to the t-type calcium channel. this suggests that higher blockage of calcium channels led to decreased membrane potential during slow-wave phases and reduced muscle contraction, compared to the physiological state.conclusion: blocking ion channels in electrophysiological models can potentially help control gastrointestinal tract motility disorders and smooth muscle contraction.