Therapeutic Effects of Adipose-Derived Mesenchymal Stem Cells on Gentamicin-Induced Renal Failure

Introduction: considering the limitations of conventional therapeutic methods in renal failure, researchers are paying attention to the application of adipose-derived mesenchymal stem cells (ad-mscs) and their protective effects against acute renal failure. this study aims to assess the therapeutic effects of ad-mscs in gentamicin-induced renal failure in rats. methods: in this study, 40 male wistar rats were studied in control, sham, gentamicin treated with and without receiving ad-mscs. after 10 days, blood samples were collected and hemodynamic parameters, malondialdehyde and ferric reducing antioxidant power (frap) measured in the right and left kidneys underwent histologic examination. results: gentamicin administration significantly increased plasma creatinine, blood urea nitrogen, oxidative stress parameters and histologic damages; while significantly reduced frap in the gentamicin-receiving group in comparison with the sham group. ad-mscs treatment significantly improved renal function parameters, oxidative stress and histologic damages in comparison with the gentamicin receiving group. conclusion: intravenous injection of ad-mscs in gentamicin-induced renal failure improved renal function, oxidative stress parameters and histologic damages.