Molecular Mechanisms and Signaling Pathways Involved In Immunopathological Events of Covid-19

Introduction: covid-19, a novel coronavirus that causes severe acute respiratory syndrome (sars-cov-2), is currently regarded as the most serious viral disease. during corona infection, viruses bind to host proteins and employ a variety of cellular pathways for their own purposes. cell signaling is important for the regulation of cellular function. sars-cov-2 infection alters multiple signal transduction pathways that are critical for cell survival. the virus causes a severe and prolonged period of hypercytokinemia with misusing of these signaling cascades. hyperactivation of the host immune system after infection with sars-cov-2 is the main cause of death in covid-19 patients. thus, to develop effective therapeutic approaches, it is necessary to first understand the problem and the underlying molecular pathways implicated in host immunological function/dysfunction. a number of intracellular signaling cascades have been implicated in infected cell pathways, including mapk pathway, nf-κb pathway, jak–stat signaling pathway, pi3k/akt/mtor pathway and tlri signaling cascades. here, we have presented the molecular insights on the potential mechanisms involved in immunopathological events of covid-19.