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synthesis and expansion of bicyclic enol ether: a probable precursor for the synthesis of macrolide (±)-pyrenophorin
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نویسنده
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costa m.b. ,martins m.p. ,araújo h.c.de ,resck i.s.
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منبع
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journal of the brazilian chemical society - 2018 - دوره : 29 - شماره : 1 - صفحه:74 -78
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چکیده
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A convenient procedure for the synthesis and expansion of bicyclic rings has been developed for the production of probable precursors of non-racemic pyrenophorin, an antibiotic dilactone. the major highlight for this new synthetic methodology came from the use of a readily available reagent of easy manipulation, 9-oxabicyclo[3.3.1]nonane-2,6-diol, for the preparation of the bicyclic intermediate, which sequentially was subjected to oxidative cleavage with butyl nitrite resulted in an isomeric mixture, a dioximedilactone and diisoxazoledilactone.
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کلیدواژه
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enol ether ,macrolides ,pyrenophorin ,ring expansion
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آدرس
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universidade estadual de goiás, laboratório de síntese, isolamento e modificações de compostos orgânicos, brazil, universidade estadual de goiás, laboratório de síntese, isolamento e modificações de compostos orgânicos, brazil, universidade de brasília, instituto de química, brazil, universidade de brasília, instituto de química, brazil
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Authors
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