; 187-195 Susceptibility of human B lymphocyte cell lines to dialysed latex B- and C-sera fractions

Hevea brasiliensis latex sera are being investigated for anticancer property. in the present cellbased assay,whole latex b- and c-sera were shown to be largely ineffective against human b lymphocytes,of both cancer origin (bdcm) and non-cancer origin (bristol 8); albeit slight dip in cell viability were discerned at high concentrations (>100 μg/ml) of whole c-serum,and (>200 μg/ml) of whole b-serum. interestingly,the antiproliferative activity improved in the reténtate of dialysed c-serum,the increment however was more prominent in the dialysed c-serum precipitate (dcp) compared to the dialysed c-serum supernatant (dcs). dcp also showed a marginally higher specificity against bdcm (lc 50 = 55.95 μg/ml) compared to bristol 8 (lc 50 = 75.62 μg/ml). however in the treatments with the retentate of dialysed b-serum,both bdcm and bristol 8 cells remained unaffected.