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The potential cardioprotective effects of hydrogenin irradiated mice
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نویسنده
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qian l. ,cao f. ,cui j. ,wang y. ,huang y. ,chuai y. ,zaho l. ,jiang h. ,cai j.
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منبع
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journal of radiation research - 2010 - دوره : 51 - شماره : 6 - صفحه:741 -747
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چکیده
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Most ionizing radiation-induced damage is caused by hydroxyl radicals,and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. irradiation of the heart can cause chronic cardiac disease. this study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen),which is easy to use,induces cardioprotection against ionizing irradiation injury in mice. in this paper,we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury,decrease myocardium malondialdehyde (mda),8-hydroxydeoxyguanosine (8-ohdg) levels,and increase myocardium endogenous antioxidants in vivo. we suggest that hydrogen has a cardioprotective effect against radiation induced injury.
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کلیدواژه
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Cardioprotection; Hydrogen; Ionizing radiation; Myocardium
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آدرس
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department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr,china,department of hematology,navy general hospital,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China, department of orthopaedics,changhai hospital,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China, department of radiation medicine,faculty of naval medicine,second military medical university,xiangyin road,200433,shanghai,pr, China
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Authors
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