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   Microdosimetric approach to NIRS-defined biological dose measurement for carbon-ion treatment beam  
   
نویسنده kase y. ,kanai t. ,sakama m. ,tameshige y. ,himukai t. ,nose h. ,matsufuji n.
منبع journal of radiation research - 2011 - دوره : 52 - شماره : 1 - صفحه:59 -68
چکیده    The rbe-weighted absorbed dose,called biological dose, has been routinely used for carbon-ion treatment planning in japan to formulate dose prescriptions for treatment protocols. this paper presents a microdosimetric approach to measuring the biological dose,which was redefined to be derived from microdosimetric quantities measured by a tissue-equivalent proportional counter (tepc). the tepc was calibrated in 60co gamma rays to assure a traceability of the tepc measurement to japanese standards and to eliminate the discrepancies among matching counters. the absorbed doses measured by the tepc were reasonably coincident with those measured by a reference ionization chamber. the rbe value was calculated from the microdosimetric spectrum on the basis of the microdosimetric kinetic model. the biological doses obtained by the tepc were compared with those prescribed in the carbon-ion treatment planning system. we found that it was reasonable for the measured biological doses to decrease with depth around the rear sobp region because of beam divergence,scattering effect,and fragmentation reaction. these results demonstrate that the tepc can be an effective tool to assure the radiation quality in carbon-ion radiotherapy.
کلیدواژه Carbon-ion radiotherapy; Microdosimetry; RBE; TEPC
آدرس research center for charged particle therapy,national institute of radiological sciences,anagawa 4-9-1,inage-ku,chiba 263-8555,japan,proton therapy division,shizuoka cancer center research institute,shimonagakubo 1007,nagaizumi-cho,shizuoka 411-8777, Japan, heavy ion medical center,gunma university,showa 3-39-22,maebashi-shi,gunma 371-8511, Japan, college of industrial technology,nihon university,izumi-cho 1-2-1,narashino-shi,chiba 275-8575, Japan, office for development of proton therapy center,regional health services division,department of health and welfare,fukui prefectural govt,yotsui 2-8-1,fukui-shi,fukui 910-8526, Japan, research center for charged particle therapy,national institute of radiological sciences,anagawa 4-9-1,inage-ku,chiba 263-8555, Japan, ihi corporation,shin-nakahara-cho 1,isogo-ku,yokohama 235-8501, Japan, research center for charged particle therapy,national institute of radiological sciences,anagawa 4-9-1,inage-ku,chiba 263-8555, Japan
 
     
   
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