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Effects of intensity-modulated radiotherapy on human oral microflora
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نویسنده
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shao z.-y. ,tang z.-s. ,yan c. ,jiang y.-t. ,ma r. ,liu z. ,huang z.-w.
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منبع
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journal of radiation research - 2011 - دوره : 52 - شماره : 6 - صفحه:834 -839
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چکیده
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This study aimed to evaluate changes in the biodiversity of the oral microflora of patients with head and neck cancer treated with postoperative intensity-modulated radiotherapy (imrt) or conventional radiotherapy (crt). pooled dental plaque samples were collected during the radiation treatment from patients receiving imrt (n = 13) and crt (n = 12). denaturing gradient gel electrophoresis (dgge) was used to analyze the temporal variation of these plaque samples. the stimulated and unstimulated salivary flow rates were also compared between imrt and crt patients. reductions in the severity of hyposalivation were observed in imrt patients compared with crt patients. we also observed that the temporal stability of the oral ecosystem was significantly higher in the imrt group (69. 96 ± 7. 82%) than in the crt group (51. 98 ± 10. 45%) (p < 0. 05). the findings of the present study suggest that imrt is more conducive to maintaining the relative stability of the oral ecosystem than crt.
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کلیدواژه
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Bacterial communities; Hyposalivation; PCR-DGGE; Radiotherapy
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آدرس
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division of radiation oncology,department of oral and maxillofacial surgery,ninth people's hospital,shanghai jiao tong university school of medicine,no. 639 zhizaoju road,shanghai 200011, China, department of endodontics,ninth people's hospital,shanghai jiao tong university school of medicine,shanghai key laboratory of stomatology,no. 639 zhizaoju road,shanghai 200011, China, department of oncology,the affiliated hospital of medical college,qingdao university,no. 308 ningxia road,qingdao 266003, China, department of endodontics,ninth people's hospital,shanghai jiao tong university school of medicine,shanghai key laboratory of stomatology,no. 639 zhizaoju road,shanghai 200011, China, department of endodontics,ninth people's hospital,shanghai jiao tong university school of medicine,shanghai key laboratory of stomatology,no. 639 zhizaoju road,shanghai 200011, China, department of endodontics,ninth people's hospital,shanghai jiao tong university school of medicine,shanghai key laboratory of stomatology,no. 639 zhizaoju road,shanghai 200011, China, department of endodontics,ninth people's hospital,shanghai jiao tong university school of medicine,shanghai key laboratory of stomatology,no. 639 zhizaoju road,shanghai 200011, China
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Authors
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