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Risk factors for rectal bleeding associated with I-125 brachytherapy for prostate cancer
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نویسنده
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harada k. ,ishikawa h. ,saito y. ,nakamoto s. ,kawamura h. ,wakatsuki m. ,etsunaga t. ,takezawa y. ,kobayashi m. ,nakano t.
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منبع
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journal of radiation research - 2012 - دوره : 53 - شماره : 6 - صفحه:923 -929
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چکیده
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The purpose of this study was to determine the risk factors for rectal bleeding after prostate brachytherapy. between april 2005 and september 2009,89 patients with t1c-2cn0m0 prostate cancer were treated with permanent i-125 seed implantation alone. the prostate prescription dose was 145 gy,and the grade of rectal bleeding was scored according to the common terminology criteria for adverse events version 4.0. post-treatment planning was performed with fusion images of computerized tomography and magnetic resonance imaging 4-5 weeks after brachytherapy. patient characteristics and dosimetric parameters were evaluated to determine risk factors for bleeding. the calculated parameters included the rectal volume in cubic centimeters that received >50-200 of the prescribed dose (rv50-200) and the minimal doses received by 1-30 of the rectal volume (rd1-30). the median follow-up time was 42 months (ranging 18-73 months). grade 1 rectal bleeding occurred in 24 (27.0) patients,but no grade 2 or severe bleeding was observed. usage of anticoagulants had a significant correlation with the occurrence of bleeding (p = 0.007). the rv100-150 and rd1-10 were significantly higher in patients with rectal bleeding than in those without bleeding. the rv100 was identified as a possible threshold value; the 3-year rectal bleeding rate in patients with an rv100 > 1.0 cm3 was 36,whereas that with an rv100 ≤ 1.0 cm3 was 14 (p < 0.05). although no grade 2 morbidity developed in this study,the rv100 should be kept below 1.0 cm3,especially in additional dose-escalated brachytherapy. © 2012 the author 2012. published by oxford university press on behalf of the japan radiation research society and japanese society for therapeutic radiology and oncology.
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کلیدواژه
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anticoagulant; brachytherapy; dose-volume-histogram; prostate cancer; rectal bleeding
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آدرس
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department of radiation oncology,isesaki municipal hospital,12-1,tsunatorimoto-machi,isesaki-shi,gunma 372-0802, Japan, department of radiation oncology,isesaki municipal hospital,12-1,tsunatorimoto-machi,isesaki-shi,gunma 372-0802, Japan, department of radiation oncology,gunma university graduate school of medicine,3-39-22 showa-machi,maebashi,gunma,371-8511, Japan, department of radiation oncology,isesaki municipal hospital,12-1,tsunatorimoto-machi,isesaki-shi,gunma 372-0802, Japan, department of radiation oncology,gunma university graduate school of medicine,3-39-22 showa-machi,maebashi,gunma,371-8511, Japan, department of radiation oncology,gunma university graduate school of medicine,3-39-22 showa-machi,maebashi,gunma,371-8511, Japan, department of radiation oncology,isesaki municipal hospital,12-1,tsunatorimoto-machi,isesaki-shi,gunma 372-0802, Japan, department of radiation oncology,isesaki municipal hospital,12-1,tsunatorimoto-machi,isesaki-shi,gunma 372-0802, Japan, department of radiation oncology,isesaki municipal hospital,12-1,tsunatorimoto-machi,isesaki-shi,gunma 372-0802, Japan, department of radiation oncology,gunma university graduate school of medicine,3-39-22 showa-machi,maebashi,gunma,371-8511, Japan
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