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Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
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نویسنده
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aoki-nakano m. ,furusawa y. ,uzawa a. ,matsumoto y. ,hirayama r. ,tsuruoka c. ,ogino t. ,nishio t. ,kagawa k. ,murakami m. ,kagiya g. ,kume k. ,hatashita m. ,fukuda s. ,yamamoto k. ,fuji h. ,murayama s. ,hata m. ,sakae t. ,matsumoto h.
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منبع
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journal of radiation research - 2014 - دوره : 55 - شماره : 4 - صفحه:812 -815
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چکیده
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We investigated the relative biological effectiveness (rbe) of therapeutic proton beams at six proton facilities in japan with respect to cell lethality of hsg cells. the rbe of treatments could be determined from experimental data. for this purpose,we used a cell survival assay to compare the cell-killing efficiency of proton beams. among the five linear accelerator (linac) x-ray machines at 4 or 6 mev that were used as reference beams,there was only a small variation (coefficient of variation cv = 3.1% at d10) in biological effectiveness. the averaged value of d10 for the proton beams at the middle position of the spread-out bragg peak (sobp) was 4.98. these values showed good agreement,with a cv of 4.3% among the facilities. thus,the average rbe10 (rbe at the d10 level) at the middle position of the sobp beam for six facilities in japan was 1.05 with a cv of 2.8%. © 2014 the author.
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کلیدواژه
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cell survival; proton therapy; relative biological effectiveness; spread-out Bragg-peak
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آدرس
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research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555,japan,kitasato university,school of allied health sciences,1-15-1 kitasato,minami-ku,sagamihara,kanagawa 252-0373, Japan, research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555, Japan, research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555, Japan, research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555, Japan, research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555, Japan, research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555, Japan, national cancer center hospital east,6-5-1 kashiwanoha,kashiwa,chiba 277-8577, Japan, national cancer center hospital east,6-5-1 kashiwanoha,kashiwa,chiba 277-8577, Japan, hyogo ion beam medical center,1-2-1 koto,shingu-cho,tatsuno-shi,hyogo 679-5165, Japan, hyogo ion beam medical center,1-2-1 koto,shingu-cho,tatsuno-shi,hyogo 679-5165,japan,proton therapy and research center,medipolis medical research institute,higashikata 5188,ibusuki,kagoshima 891-0304,japan,dokkyo medical university,880 kitakobayashi,mibu-machi,shimotsuga-gun,tochigi 321-0293, Japan, wakasa wan energy research center,64-52-1 nagatani,tsuruga,fukui 914-0192,japan,kitasato university,school of allied health sciences,1-15-1 kitasato,minami-ku,sagamihara,kanagawa 252-0373, Japan, wakasa wan energy research center,64-52-1 nagatani,tsuruga,fukui 914-0192, Japan, wakasa wan energy research center,64-52-1 nagatani,tsuruga,fukui 914-0192, Japan, research center for particle therapy,national institute of radiological sciences,4-9-1 anagawa,inage-ku,chiba 263-8555,japan,wakasa wan energy research center,64-52-1 nagatani,tsuruga,fukui 914-0192, Japan, wakasa wan energy research center,64-52-1 nagatani,tsuruga,fukui 914-0192,japan,proton therapy center,fukui prefectural hospital,2-8-1,yotsui,fukui 910-8526, Japan, shizuoka cancer center,1007 shimonagakubo,nagaizumi-cho,sunto-gun,shizuoka 411-8777, Japan, shizuoka cancer center,1007 shimonagakubo,nagaizumi-cho,sunto-gun,shizuoka 411-8777, Japan, proton medical research center,university of tsukuba,2-1-1 amakubo,tsukuba,ibaraki 365-8576,japan,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,kanagawa 236-0004, Japan, proton medical research center,university of tsukuba,2-1-1 amakubo,tsukuba,ibaraki 365-8576, Japan, university of fukui,23-3 matsuoka-shimoaizuki,eiheiji-cho,yoshida-gun,fukui 910-1193, Japan
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Authors
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