Validity of reduced radiation dose for localized diffuse large B-cell lymphoma showing a good response to chemotherapy

To evaluate the validity of a decrease in the radiation dose for patients who were good responders to chemotherapy for localized diffuse large b-cell lymphoma (dlbcl),91 patients with localized dlbcl who underwent radiotherapy after multi-agent chemotherapy from 1988-2008 were reviewed. exclusion criteria were as follows: central nervous system or nasal cavity primary site,or stage ii with bulky tumor (≥10 cm). of these patients,62 were identified as good responders to chemotherapy. they were divided into two groups receiving either a higher or a lower radiation dose (32-50.4 gy or 15-30.6 gy,respectively). there were no statistically significant differences between the lower and higher dose groups in progression-free survival,locoregional progression-free survival or overall survival. adaptation of decreased radiation dose may be valid for localized dlbcl patients who show a good response to chemotherapy. © 2013 the author 2013. published by oxford university press on behalf of the japan radiation research society and japanese society for therapeutic radiology and oncology.