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Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures
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نویسنده
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hu w. ,pei h. ,li h. ,ding n. ,he j. ,wang j. ,furusawa y. ,hirayama r. ,matsumoto y. ,liu c. ,li y. ,kawata t. ,zhou g.
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منبع
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journal of radiation research - 2014 - دوره : 55 - شماره : 1 - صفحه:10 -16
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چکیده
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High atomic number and high-energy (hze) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. however,simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. in this study,we investigated the biological effects of secondary radiation with two cell types,and with cells exposed in different phases of the cell cycle,by comparing the biological effects of a 200 mev/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 mev/u to 200 mev/u with pmma,polyethylene (pe),or aluminum. we found that beam shielding resulted in increased induction of 53bp1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 mev/u fe ion beam. these findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between hze particles and shielding materials should be considered in shielding design. © 2013 the author.
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کلیدواژه
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DNA damage; secondary particles; shielding; space radiation; survival
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آدرس
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department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000,china,university of chinese academy of sciences,beijing 100049, China, department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000,china,university of chinese academy of sciences,beijing 100049, China, department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000, China, department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000,china,university of chinese academy of sciences,beijing 100049, China, department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000,china,university of chinese academy of sciences,beijing 100049, China, department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000, China, research center for charged particle therapy,national institute of radiological sciences,chiba 263-555, Japan, research center for charged particle therapy,national institute of radiological sciences,chiba 263-555, Japan, research center for charged particle therapy,national institute of radiological sciences,chiba 263-555, Japan, research center for charged particle therapy,national institute of radiological sciences,chiba 263-555, Japan, state key laboratory of space medical fundamentation,application astronaut center of china,beijing 100094, China, department of radiology,school of medicine,keio university,tokyo,160-8582, Japan, department of space radiobiology,key laboratory of heavy ion radiation biology and medicine,chinese academy of sciences,509 nanchang road,lanzhou 730000, China
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Authors
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