Current status and outcomes of patients developing PSA recurrence after prostatectomy who were treated with salvage radiotherapy: A JROSG surveillance study

The conditions and outcomes of japanese patients with prostate cancer who developed psa failure after radical prostatectomy (rp),and who were treated via salvage radiotherapy (s-rt),were surveyed. clinical data on s-rt were gathered in questionnaires completed by facilities participating in the japanese radiation oncology study group. s-rt was defined as external-beam radiotherapy delivered to the prostate beds of patients with prostate cancer who had eventually developed psa failure,although their psa values had at one stage attained levels <0.2 ng/ml following rp. hormonal therapy was combined with s-rt in ∼40% of cases. outcomes were evaluated in 186 cases treated via s-rt alone. the nadir psa level after rp,and the level upon initiation of s-rt,were 0.0135 ng/ml and 0.292 ng/ml,respectively. the median period between rp and s-rt was 18.6 months. the median follow-up period was 58 months. the 5-year psa recurrence-free survival (prfs) and clinical failure-free survival (cffs) rates were 50.1% (95% ci: 42.8-57.9%) and 90.1% (95% ci: 86.4-95.7%),respectively. prfs was significantly superior in patients with psa values ≤0.3 ng/ml upon initiation of s-rt than in those with psa values >0.3 ng/ml (57.5% vs 40.5%,p = 0.027). in japan,hormonal therapy is combined with s-rt in ∼40% of cases. the 5-year prfs and cffs rates of cases treated via s-rt alone were 50.1% and 90.1%,respectively. a psa value of 0.3 ng/ml served as a significant cut-off for prediction of prfs. © the author 2015.