Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: A multi-institutional retrospective research study

The purpose of this study was to analyze the patterns of care and outcomes of patients with figo stage i/ii cervical cancer who underwent definitive radiotherapy (rt) at multiple japanese institutions. the japanese radiation oncology study group (jrosg) performed a questionnaire-based survey of their cervical cancer patients who were treated with definitive rt between january 2000 and december 2005. a total of 667 patients were entered in this study. although half of the patients were considered suitable for definitive rt based on the clinical features of the tumor,about one-third of the patients were prescribed rt instead of surgery because of poor medical status. the rt schedule most frequently utilized was whole-pelvic field irradiation (wp) of 30 gy/15 fractions followed by wp with midline block of 20 gy/10 fractions,and high-dose-rate intracavitary brachytherapy (hdr-icbt) of 24 gy/4 fractions prescribed at point a. chemotherapy was administered to 306 patients (46%). the most frequent regimen contained cisplatin (cddp). the median follow-up time for all patients was 65 months (range,2-135 months). the 5-year overall survival (os),pelvic control (pc) and disease-free survival (dfs) rates for all patients were 78%,90% and 69%,respectively. tumor diameter and nodal status were significant prognostic indicators for os,pc and dfs. chemotherapy has potential for improving the os and dfs of patients with bulky tumors,but not for non-bulky tumors. this study found that definitive rt for patients with stage i/ii cervical cancer achieved good survival outcomes. © 2015 the author 2015. published by oxford university press on behalf of the japan radiation research society and japanese society for radiation oncology.