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DNA damage response induces structural alterations in histone H3-H4
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نویسنده
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izumi y. ,fujii k. ,yamamoto s. ,matsuo k. ,namatame h. ,taniguchi m. ,yokoya a.
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منبع
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journal of radiation research - 2017 - دوره : 58 - شماره : 1 - صفحه:59 -65
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چکیده
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Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the dna damage response induces a decrement of α-helix and an increment of β-strand contents of histone h3-h4 extracted from x-ray-irradiated human hela cells. the trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone h2a-h2b. these results strongly suggest that histones share roles in dna damage responses,particularly in dna repair processes and chromatin remodeling,via a specific structural alteration of each histone. © the author 2016. published by oxford university press on behalf of the japan radiation research society and japanese society for radiation oncology.
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کلیدواژه
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Chromatin remodeling; Circular dichroism; DNA repair; Histone dynamics; Post-translational modification; Synchrotron radiation
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آدرس
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hiroshima synchrotron radiation center,hiroshima university,2-313 kagamiyama,higashi-hiroshima,hiroshima 739-0046, Japan, national institutes for quantum and radiological science and technology (qst),2-4,ooaza-shirakata,tokai,naka,ibaraki 319-1106, Japan, graduate school of science and engineering,ibaraki university,2-1-1,bunkyo,mito,ibaraki 310-0056, Japan, hiroshima synchrotron radiation center,hiroshima university,2-313 kagamiyama,higashi-hiroshima,hiroshima 739-0046, Japan, hiroshima synchrotron radiation center,hiroshima university,2-313 kagamiyama,higashi-hiroshima,hiroshima 739-0046, Japan, hiroshima synchrotron radiation center,hiroshima university,2-313 kagamiyama,higashi-hiroshima,hiroshima 739-0046, Japan, national institutes for quantum and radiological science and technology (qst),2-4,ooaza-shirakata,tokai,naka,ibaraki 319-1106,japan,graduate school of science and engineering,ibaraki university,2-1-1,bunkyo,mito,ibaraki 310-0056, Japan
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Authors
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