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Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder
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نویسنده
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romanos m. ,weise d. ,schliesser m. ,schecklmann m. ,löffler j. ,warnke a. ,gerlach m. ,classen j. ,mehler-wex c.
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منبع
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journal of psychiatry and neuroscience - 2010 - دوره : 35 - شماره : 1 - صفحه:55 -58
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چکیده
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Background: structural abnormality of the substantia nigra can be detected by transcranial sonography in neuropsychiatric disorders such as parkinson disease and restless legs syndrome. we investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (adhd). methods: we used a blinded design and determined echogenicity of the substantia nigra by use of transcranial sonography in 22 children with adhd and 22 healthy controls matched for age and sex. results: the echogenic substantia nigra area was significantly larger in adhd patients than in healthy controls ( f1,42 = 9.298,p = 0.004,effect size = 0.92). we found no effects of age or sex. limitations: owing to a lack of dimensional assessment,we could not analyze the correlation between echogenicity and clinical symptoms. conclusion: our results support the hypothesis that the nigrostriatal dopaminergic system is abnormal in children with adhd. © 2010 canadian medical association.
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آدرس
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department of child and adolescent psychiatry,psychosomatics and psychotherapy,university hopital of wuerzburg,fuechsleinstr. 15,97080 wuerzburg, Germany, department of neurology,university hospital of wuerzburg,wuerzburg,germany,department of neurology,university hospital of leipzig,leipzig, Germany, department of neurology,university hospital of wuerzburg,wuerzburg, Germany, department of psychiatry,psychosomatics and psychotherapy,university hospital of wuerzburg,wuerzburg, Germany, department of child and adolescent psychiatry,psychosomatics and psychotherapy,university hopital of wuerzburg,fuechsleinstr. 15,97080 wuerzburg,germany,leopoldina hospital,department of child and adolescent psychiatry and psychotherapy,university hospital of ulm,ulm, Germany, department of child and adolescent psychiatry,psychosomatics and psychotherapy,university hopital of wuerzburg,fuechsleinstr. 15,97080 wuerzburg, Germany, department of child and adolescent psychiatry,psychosomatics and psychotherapy,university hopital of wuerzburg,fuechsleinstr. 15,97080 wuerzburg, Germany, department of neurology,university hospital of wuerzburg,wuerzburg,germany,department of neurology,university hospital of leipzig,leipzig, Germany, department of child and adolescent psychiatry/psychotherapy,university hospital of ulm,ulm, Germany
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Authors
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