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Effects of trauma-related cues on pain processing in posttraumatic stress disorder: An fMRI investigation
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نویسنده
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mickleborough m.j.s. ,daniels j.k. ,coupland n.j. ,kao r. ,williamson p.c. ,lanius u.f. ,hegadoren k. ,schore a. ,densmore m. ,stevens t. ,lanius r.a.
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منبع
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journal of psychiatry and neuroscience - 2011 - دوره : 36 - شماره : 1 - صفحه:6 -14
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چکیده
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Background: imaging studies of pain processing in primary psychiatric disorders are just emerging. this study explored the neural correlates of stress-induced analgesia in individuals with posttraumatic stress disorder (ptsd). it combined functional magnetic resonance imaging (fmri) and the traumatic script-driven imagery symptom provocation paradigm to examine the effects of trauma-related cues on pain perception in individuals with ptsd. methods: the study included 17 patients with ptsd and 26 healthy,trauma-exposed controls. participants received warm (nonpainful) or hot (painful) thermal stimuli after listening to a neutral or a traumatic script while they were undergoing an fmri scan at a 4.0 t field strength. results: between-group analyses revealed that after exposure to the traumatic scripts,the blood oxygen level-dependent (bold) signal during pain perception was greater in the ptsd group than the control group in the head of the caudate. in the ptsd group,strong positive correlations resulted between bold signal and symptom severity in a number of brain regions previously implicated in stress-induced analgesia,such as the thalamus and the head of the caudate nucleus. trait dissociation as measured by the dissociative experiences scale correlated negatively with the right amygdala and the left putamen. limitations: this study included heterogeneous traumatic experiences,a different proportion of military trauma in the ptsd versus the control group and medicated patients with ptsd. conclusion: these data indicate that in patients with ptsd trauma recall will lead in a state-dependent manner to greater activation in brain regions implicated in stress-induced analgesia. correlational analyses lend support to cortical hyperinhibition of the amygdala as a function of dissociation. © 2011 canadian medical association.
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آدرس
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neuroscience program,university of british columbia,vancouver,bc, Canada, department of psychiatry,university of western ontario,university hospital,339 windermere rd,london,on n6a 2a2, Canada, department of psychiatry,university of alberta,edmonton,ab, Canada, department of medicine,university of western ontario,and critical care medicine,london health sciences centre,london,on, Canada, department of psychiatry,university of western ontario,university hospital,339 windermere rd,london,on n6a 2a2,canada,department of neuroscience,university of western ontario,london,on, Canada, the sensorimotor psychotherapy institute,boulder,co, United States, faculty of nursing,university of alberta,edmonton,ab, Canada, department of psychiatry and biobehavioral sciences and center for culture,brain and development,university of california los angeles,ca, United States, neuroscience program,university of british columbia,vancouver,bc, Canada, department of chemistry,university of california,berkeley,ca, United States, department of psychiatry,university of western ontario,university hospital,339 windermere rd,london,on n6a 2a2,canada,department of neuroscience,university of western ontario,london,on, Canada
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Authors
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