>
Fa   |   Ar   |   En
   Effect of venlafaxine and nicotine on the level of neurotransmitters and their metabolites in rat brains  
   
نویسنده czubak a. ,nowakowska e. ,golembiowska k. ,kus k. ,burda k. ,metelska j.
منبع journal of physiology and pharmacology - 2010 - دوره : 61 - شماره : 3 - صفحه:339 -346
چکیده    Nicotine (nic) and venlafaxine (ven) have been proved to exert antidepressant activity in both human and animals. the effect of antidepressant doses of nic and ven (our previous results) on noradrenergic (na),dopaminergic (da),serotoninergic (5-ht) neurotransmitters and their metabolites: dopac,hvaand 5-hiaain rats' hippocampus in freely moving rats were determined by microdialysis technique and hplc method. both drugs release 5-ht and na,but ven to a greater degree. da level was affected only by ven,however nic extended the response of the da system on ven's effect. combined administration of drugs caused the greatest changes in the 5-ht system. both drugs contributed to reduction in neurotransmitter biotransformation.
کلیدواژه Dopamine; Hippocampus; Microdialysis; Neurotransmitters; Nicotine; Noradrenaline; Venlafaxine
آدرس department of pharmacoeconomics and social pharmacy,karol marcinkowski university of medical sciences,poznan, Poland, department of pharmacoeconomics and social pharmacy,karol marcinkowski university of medical sciences,poznan, Poland, institute of pharmacology,polish academy of sciences,cracow, Poland, department of pharmacoeconomics and social pharmacy,karol marcinkowski university of medical sciences,poznan, Poland, department of pharmacoeconomics and social pharmacy,karol marcinkowski university of medical sciences,poznan, Poland, department of pharmacoeconomics and social pharmacy,karol marcinkowski university of medical sciences,poznan, Poland
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved