Metabolic syndrome in type 1 diabetes mellitus. does it have any impact on the course of pregnancy?

To determine whether the symptoms of metabolic syndrome (ms),if accompanied by oxidative stress (os),in type1 diabetes mellitus (dm) patients could affect the course of pregnancy and the perinatal outcome. oxidized low density lipoproteins (ox-ldl) and total lipid peroxides (tlp) were studied in 98 pregnant women with type 1 dm in the ist and iiird trimesters. 24% of the participants met the criteria of ms. vascular complications were significantly more frequent in the ms-group (41.9% vs. 17.4% in the non-ms group,p<0.05). no differences in the markers of os between the ms and the non-ms groups were noted in either the ist or the iiird trimester. asignificant gestational rise in per-ox was found in both groups. chronic hypertension was associated with significant differences in ox-ldl levels in both the ist and iiird trimester. no differences in perinatal outcome,as measured by abnormal birth weight or poor neonatal status (apgar score<6,umbilical venous and/or arterial ph<7.20),were found. conclusions: 1) ms in type 1 dm is associated with some changes in markers of oxidative stress,but it poses no additional risk to the course of pregnancy and perinatal outcome in properly controlled and treated pregnant women with type 1 dm. 2) maternal hypertension is the only component of ms in diabetic pregnancy that is associated with significant changes in markers of oxidative stress. 3) ms is significantly more frequent in diabetic pregnant women with co-existing vascular complications and obesity.