Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells

Palm oil is rich in various health-beneficial phytonutrients. the vitamin e and the carotenoids make up a large portion of these phytonutrients. the tocotrienols are a relatively newer class of vitamin e isoforms that are actively being researched for its various health promoting properties. in this study,the anti-cancer properties of the delta-tocotrienol (δ-t3) isoform were investigated on a leukemic cell line. a preliminary cytotoxicity assay was carried out to identify δ-t3's potency in inducing cell death. following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by δ-t3 in the k562 leukemic cell line. results show that treatment with δ-t3 significant regulated the expression of several genes that promote apoptosis such as tp53,tp73,hrk,mcl1,casp7,casp8,dapk1,pycard,faslg and tnfrsf9. these findings suggest that palm δ-t3 can exert anti-cancer activities in chronic myeloid leukemic cells.