significance of 11 c-pib pet/ct in cardiac amyloidosis compared with 99m tc-aprotinin scintigraphy: a pilot study

This study was to investigate the significance of 11c-pittsburgh b (pib) pet/ct in patients with suspected cardiac amyloidosis compared with 99mtc-aprotinin scintigraphy. thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. participants were scheduled to undergo a series of 11c-pib pet/ct and 99mtc-aprotinin within a 2-month period. finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis. six of the 9 patients who underwent both imaging modalities were diagnosed with amyloidosis, of whom 3 patients were diagnosed with cardiac amyloidosis from endomyocardial biopsy. these 3 patients with positive 11c-pib uptake at the left ventricle wall showed worsening of cardiac function progressing in the short term or death caused by acute exacerbation of chronic heart failure. six of 8 patients with positive uptake on 99mtc-aprotinin presented with amyloid deposition in the left ventricle wall, but symptoms remained stable if results of 11c-pib were not positive. in a small sample of subjects, the present study showed that 11c-pib accumulation in myocardium indicated cardiac amyloidosis with poor prognosis. uptake of 11c-pib be related to progressive amyloid deposition to the heart and can predict patient prognosis.