left ventricular eccentricity index measured with spect myocardial perfusion imaging: an additional parameter of adverse cardiac remodeling

Single-photon emission computed-tomography (spect) allows the quantification of lv eccentricity index (ei), a measure of cardiac remodeling. we sought to evaluate the feasibility of ei measurement with spect myocardial perfusion imaging and its interactions with relevant lv functional and structural parameters. four-hundred and fifty-six patients underwent myocardial perfusion imaging on a cadmium-zinc-telluride (czt) camera. the summed rest, stress, and difference scores were calculated. from rest images, the lv end-diastolic (edv) and end-systolic volumes, ejection fraction (ef), and peak filling rate (pfr) were calculated. in every patient, the ei, ranging from 0 (sphere) to 1 (line), was computed using a dedicated software (qgs/qps; cedars-sinai medical center). three-hundred and thirty-eight/456 (74%) patients showed a normal ef (>50%), while 26% had lv systolic dysfunction. the ei was computed from czt images with excellent reproducibility (interclass correlation coefficient: 0.99, 95% ci 0.98-0.99). more impaired ei values correlated with the presence of a more abnormal lv perfusion (p < .001), function (ef and pfr, p < .001), and structure (edv, p < .001). on multivariate analysis, higher edv (p < .001) and depressed ef (p = .014) values were independent predictors of abnormal ei. the evaluation of lv eccentricity is feasible on gated czt images. abnormal ei associates with significant cardiac structural and functional abnormalities.