relationship of 82 rb pet territorial myocardial asynchrony to arterial stenosis

82rb pet/ct rest/regadenoson-stress data enable quantification of left ventricular rest and stress function, perfusion, and asynchrony. our study was conducted to determine which parameters best identify patients with multi-vessel disease (mvd) and individual stenosed arteries. pet/ct data were reviewed retrospectively for 105 patients referred for evaluation of cad, who also underwent angiography. % arterial stenosis was determined quantitatively at a core laboratory. severe stenosis was defined as ≥ 70%, and mvd as 2 or more stenosed arteries. segmental mbf was calculated from first-pass data for arterial territories. regional rest and stress systolic and diastolic asynchrony (asynch) scores were determined from visual examination of phase polar maps. 65 vessels had stenoses ≥ 70%. 15 patients had mvd. roc area under curve (roc auc) for identifying patients with mvd was 83% for asynch and 73% for mfr. roc auc for identifying individual arterial territories with stenoses ≥ 70% was 81% and 72% for asynch and mfr. 82rb pet/ct accurately identified patients with mvd and individual stenosed territories, with regional asynchrony measurements contributing significantly to identify patients with cad.