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mechanical contraction to guide crt left-ventricular lead placement instead of electrical activation in myocardial infarction with left ventricular dysfunction: an experimental study based on non-invasive gated myocardial perfusion imaging and invasive electroanatomic mapping
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نویسنده
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wang jianfeng ,wang yuetao ,yang minfu ,shao shan ,tian yi ,shao xiaoliang ,fan shengdeng ,zhang feifei ,yang wei ,xin wenchong ,tang haipeng ,xu min ,yang ling ,wang xiaosong ,zhou weihua
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منبع
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journal of nuclear cardiology - 2020 - دوره : 27 - شماره : 2 - صفحه:419 -430
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چکیده
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Whether the region of the latest electrical activation (lea) corresponds with the segment of the latest mechanical contraction (lmc) in ischemic cardiomyopathy (icm) is uncertain. we aimed to investigate the relationship between the left-ventricular (lv) viable segments with lea and with lmc after myocardial infarction (mi) and analyze the acute hemodynamic responses (dp/dtmax) after cardiac resynchronization therapy (crt) pacing at different lv sites. bama suckling pigs (n = 6) were subjected to create mi models. both gated myocardial perfusion imaging (gmpi) and electroanatomic mapping (eam) were performed successfully before mi and 4 weeks after mi. lmc was assessed by phase analysis of gmpi, while lea was evaluated by eam. the dp/dtmax was measured before crt and when the crt lv electrode was implanted in viable segments of lmc, viable segments of lateral wall and scar, respectively. the viable segments of lea were consistent with the sites of lmc for five in six cases. the dp/dtmax increased significantly compared with that before crt when the crt lv electrode was implanted in viable segments of lmc (1103.33 ± 195.76 vs 717.83 ± 80.74 mmhg·s−1, p = .001), which was also significantly higher than in viable segments of lateral wall (751.17 ± 105.62 mmhg·s−1, p = .000) and scar (679.50 ± 60.87 mmhg·s−1, p = .001). non-invasive gmpi be a better option than invasive eam for guiding lv electrode implantation for crt in icm.
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کلیدواژه
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cardiac resynchronization therapy ,gated spect ,dyssynchrony ,myocardial infarction ,latest mechanical contraction
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آدرس
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the third affiliated hospital of soochow university, department of nuclear medicine, china, the third affiliated hospital of soochow university, department of nuclear medicine, china, capital medical university, beijing chaoyang hospital, department of nuclear medicine, china, the third affiliated hospital of soochow university, department of cardiology, china, capital medical university, beijing anzhen hospital, department of nuclear medicine, china, the third affiliated hospital of soochow university, department of nuclear medicine, china, the third affiliated hospital of soochow university, department of anesthesiology, china, the third affiliated hospital of soochow university, department of nuclear medicine, china, the third affiliated hospital of soochow university, department of nuclear medicine, china, the third affiliated hospital of soochow university, department of nuclear medicine, china, university of southern mississippi, school of computing, usa, the third affiliated hospital of soochow university, department of echocardiogram, china, the third affiliated hospital of soochow university, department of cardiology, china, the third affiliated hospital of soochow university, department of nuclear medicine, china, university of southern mississippi, school of computing, usa
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Authors
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