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simplified quantification of 13 n-ammonia pet myocardial blood flow: a comparative study with the standard compartment model to facilitate clinical use
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نویسنده
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chang chih-yung ,hung guang-uei ,hsu bailing ,yang bang-hung ,chang chi-wei ,hu lien-hsin ,huang wen-sheng ,wang hsin-ell ,wu tao-cheng ,liu ren-shyan
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منبع
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journal of nuclear cardiology - 2020 - دوره : 27 - شماره : 3 - صفحه:819 -828
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چکیده
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Short imaging protocol to quantify myocardial blood flow (mbf) and myocardial flow reserve (mfr) enhance the clinical application of 13n-ammonia cardiac pet. we assessed the flow quantitation of 13n-ammonia pet implementing simple retention model and two-compartment model. fourteen healthy volunteers (hvt) and twenty-three clinical patients received 13n-ammonia pet/ct. the simple retention model used the first 7-minute image to quantify mbf. global and regional mbf and mfr of the two models were compared. global and regional mbf and mfr of these two models were highly correlated with mildly inferior correlation in rca territory (global r2: rest mbf = 0.79, stress mbf = 0.65, mfr = 0.77; regional r2: rest mbf ≥ 0.72, stress mbf ≥ 0.52, mfr ≥ 0.68). there were significant differences for mfr (4.04 ± 0.72, 3.66 ± 0.48, p = .02) and rest mbf (0.69 ± 0.12, 0.78 ± 0.12, p = .02) between the two models in the hvt group. 13n-ammonia global and regional mbf and mfr from the simple retention model demonstrate strong correlations with that from the two-compartment model. significant differences of mfr and rest mbf are noted in the hvt group, with a proposed normal reference value for the 13n-ammonia short simple retention protocol.
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کلیدواژه
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myocardial blood flow quantitation ,13n-ammonia pet ,simple retention model ,two-compartment model ,coronary artery disease
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آدرس
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taipei veterans general hospital and national yang-ming university, department of nuclear medicine, taiwan. national yang-ming university, school of biomedical science and engineering, department of biomedical imaging and radiological sciences, taiwan. national defense medical center, school of medicine, taiwan, chang bing show chwan memorial hospital, department of nuclear medicine, taiwan, national yang-ming university, school of biomedical science and engineering, department of biomedical imaging and radiological sciences, taiwan, taipei veterans general hospital and national yang-ming university, department of nuclear medicine, taiwan. national yang-ming university, school of biomedical science and engineering, department of biomedical imaging and radiological sciences, taiwan, taipei veterans general hospital and national yang-ming university, department of nuclear medicine, taiwan, taipei veterans general hospital and national yang-ming university, department of nuclear medicine, taiwan, taipei veterans general hospital and national yang-ming university, department of nuclear medicine, taiwan. national yang-ming university, school of biomedical science and engineering, department of biomedical imaging and radiological sciences, taiwan. national defense medical center, school of medicine, taiwan, national yang-ming university, school of biomedical science and engineering, department of biomedical imaging and radiological sciences, taiwan, taipei veterans general hospital and national yang-ming university, division of cardiology, department of medicine, taiwan, taipei veterans general hospital and national yang-ming university, department of nuclear medicine, taiwan. national yang-ming university, school of biomedical science and engineering, biomedical imaging research center, department of biomedical imaging and radiological sciences, taiwan. molecular and genetic imaging core, taiwan animal consortium, taiwan. cheng hsin general hospital, department of nuclear medicine, taiwan
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Authors
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