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   characterization of a highly effective preparation for suppression of myocardial glucose utilization  
   
نویسنده larson sophia r. ,pieper justin a. ,hulten edward a. ,ficaro edward p. ,corbett james r. ,murthy venkatesh l. ,weinberg richard l.
منبع journal of nuclear cardiology - 2020 - دوره : 27 - شماره : 3 - صفحه:849 -861
چکیده    With appropriate protocols, f-18 fluorodeoxyglucose (fdg) positron emission tomography/computed tomography (pet/ct) can visualize myocardial inflammation. optimal protocols and normative myocardial fdg uptake values are not well-established. we evaluated 111 patients referred for inflammation cardiac fdg pet/ct. patients followed a low-carbohydrate, high-fat diet for 36 hours before imaging and received unfractionated heparin. glucose and fatty acid metabolism biomarkers were obtained. mean blood pool and maximum myocardial uptake (suvmean, suvmax) were measured, avoiding areas of abnormal fdg uptake or spillover. adequate suppression of myocardial fdg uptake occurred in 95% of patients (n = 106). myocardial suvmax was significantly below background blood pool suvmean: septal myocardial to blood pool ratio 0.75 (95% ci 0.73-0.77; p < 0.001); lateral myocardial to blood pool ratio 0.70 (95% ci 0.68-0.72; p < 0.001). glucose, insulin, and c-peptide correlated to blood pool suvmean (spearman rs = 0.39, p < 0.01; rs = 0.40, p < 0.01; rs = 0.35, p < 0.01) and myocardial suvmax (spearman rs = 0.31, p < 0.01; rs = 0.31, p < 0.01; rs = 0.26, p < 0.01). fatty acid metabolism biomarkers did not correlate to myocardial suvmax. patients following intensive metabolic preparation have myocardial fdg suvmax below background suvmean. biomarkers of glucose metabolism modestly correlate to fdg uptake.
کلیدواژه pet/ct ,fdg ,myocardial inflammation ,metabolic preparation
آدرس university of michigan, department of medicine, usa, university of michigan, department of medicine, usa, va and uniformed services university, fort belvoir community hospital, usa, invia medical imaging solutions, usa, university of michigan, division of cardiovascular medicine, department of medicine, division of nuclear medicine, department of radiology, usa, university of michigan, division of cardiovascular medicine, department of medicine, division of nuclear medicine, department of radiology, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa
 
     
   
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