performance of 99m tc-aprotinin scintigraphy for diagnosing light chain (al) cardiac amyloidosis confirmed by endomyocardial biopsy

Light chain (al) cardiac amyloidosis is associated with a poor prognosis. diagnosing at an early stage is critical for treatment and the management of cardiac complication. we aimed to evaluate the diagnostic performance of 99mtc-aprotinin images in patients with al cardiac amyloidosis. 99mtc-aprotinin scintigraphy and endomyocardial biopsy were performed in 10 patients with suspected amyloidosis. endomyocardial biopsy showed amyloid deposits in 5 of 10 patients. 99mtc-aprotinin (planer image) was positive in 4 of 5 patients who had amyloid deposits in endomyocardial biopsy. on the other hand, all 5 patients without amyloid deposits were negative in planer image. 99mtc-aprotinin (spect/ct image) was positive in all 5 patients who had amyloid deposits. 99mtc-aprotinin scintigraphy is valuable for the non-invasive diagnosis of al cardiac amyloidosis.