left ventricular dyssynchrony and abnormalities in wall motion, assessed by gated-spect as ischemic auxiliary markers

Left ventricular dyssynchrony (lvd) quantified by gated myocardial perfusion studies (mps), through phase analysis (pa), has shown controversial results in myocardial stunning. assessment of lvd and regional wall motion abnormalities (rwma) in normal and ischemic patients. a cohort of 172 patients were studied. summed stress score (sss), summed resting score (srs), and summed difference score (sds) were evaluated. group 1-patients with normal mps (n = 133) and group 2-patients with myocardial ischemia in the mps (n = 39). lvd was evaluated through pa and rwm by visual analysis. sss 0 vs 9.8 ± 3.9 p = .0001; sds 0 vs 9.8 ± 3.9 p = .0001; srs 0 vs 0 p = ns, in g1 and g2. significant differences were found in lvd between g1 and g2, bandwidth 36 ± 14 vs 63 ± 46 p = .0001; standard deviation 16 ± 10 vs 26 ± 15 p = .0001. in g1, 16% had lvd vs rwma in 0%, p = .0001 and in g2, 59% with lvd vs 33% with rwma, p = .03. sensitivity for lvd 59% and for rwma 33%, p = .03 and specificity for lvd 83% and for rwma 100%, p = .0001. ischemic patients have lvd post-stress due to myocardial stunning. lvd measured by pa could be a useful tool to identify ischemia.