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comparison of the dyssynchrony parameters recorded with gated spect in ischemic cardiomyopathy according to their repeatability at rest and to their ability to detect a synchrony reserve under dobutamine infusion
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نویسنده
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legallois damien ,marie pierre-yves ,franken philippe r. ,djaballah wassila ,agostini denis ,manrique alain
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منبع
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journal of nuclear cardiology - 2020 - دوره : 27 - شماره : 6 - صفحه:2247 -2257
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چکیده
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This study aimed to determine whether the repeatability of dyssynchrony assessment using gated myocardial perfusion spect (gspect) allows the detection of synchrony reserve during low-dose dobutamine infusion. sixty-one patients with ischemic cardiomyopathy and lv ejection fraction < 50% were prospectively included in 10 centers. each patient underwent two consecutive rest gspect with 99mtc-labeled tracer (either tetrofosmin or sestamibi) to assess the repeatability of lv function and dyssynchrony parameters, followed by a gsect acquisition during low-dose dobutamine infusion. lv dyssynchrony was assessed using qgs software through histogram bandwidth (bw), standard deviation of the phase (sd), and entropy. repeatability was assessed with lin’s concordance correlation coefficient (ccc). entropy showed a higher ccc (0.80) compared to bw (0.68) and sd (0.75). on average, dobutamine infusion yielded to improve both bw (p = .049) and entropy (p = .04) although significant improvements, setting outside the 95% confidence interval of the repeatability analysis, were documented in only 6 and 4 patients for bw and entropy, respectively. a synchrony reserve be documented in patients with ischemic cardiomyopathy through the recording of bw and entropy with low-dose dobutamine gspect, with the additional advantage of a higher repeatability for entropy.
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کلیدواژه
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gated single-photon emission computed tomography ,heart failure ,ischemic cardiomyopathy ,left ventricular dyssynchrony ,dobutamine infusion
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آدرس
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normandie université, france. department of cardiology, chu de caen, france, department of nuclear medicine, chu de nancy, france, az-vub nuclear medicine jette, belgium, department of nuclear medicine, chu de nancy, france, normandie université, france. department of nuclear medicine, chu de caen, france, normandie université, france. department of nuclear medicine, chu de caen, france. gip cyceron pet center, france
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Authors
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