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   ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: a 13 n-ammonia pet study  
   
نویسنده juarez-orozco luis eduardo ,monroy-gonzalez andrea g. ,zant friso m. van der ,hoogvorst nick ,slart riemer h. j. a. ,knol remco j. j.
منبع journal of nuclear cardiology - 2020 - دوره : 27 - شماره : 6 - صفحه:2234 -2242
چکیده    It is thought that heart failure (hf) patients benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. we explore the relationship between quantitative myocardial perfusion and synchrony parameters when accounting for the presence and extent of fixed perfusion defects in patients with chronic hf. we studied 98 patients with chronic hf who underwent rest and stress nitrogen-13 ammonia pet. multivariate analyses of covariance were performed to determine relevant predictors of synchrony (measured as bandwidth, standard deviation, and entropy). in our population, there were 43 (44%) women and 55 men with a mean age of 71 ± 9.6 years. the srs was the strongest independent predictor of mechanical synchrony variables (p < .01), among other considered predictors including: age, sex, body mass index, smoking, diabetes mellitus, dyslipidemia, hypertension, rest myocardial blood flow (mbf), and myocardial perfusion reserve (mpr). results were similar when considering stress mbf instead of mpr. the existence and extent of fixed perfusion defects, but not the quantitative pet myocardial perfusion parameters (smbf and mpr), constitute a significant independent predictor of ventricular mechanical synchrony in patients with chronic hf.
کلیدواژه positron emission tomography ,myocardial perfusion ,mechanical synchrony ,heart failure
آدرس university medical center groningen, department of nuclear medicine and molecular imaging, the netherlands. turku university hospital and university of turku, turku pet centre, finland, university medical center groningen, department of nuclear medicine and molecular imaging, the netherlands, northwest clinics, cardiac imaging division alkmaar, department of nuclear medicine, the netherlands, northwest clinics, cardiac imaging division alkmaar, department of nuclear medicine, the netherlands, university medical center groningen, department of nuclear medicine and molecular imaging, the netherlands. university of twente, techmed centre, department of biomedical photonic imaging, the netherlands, northwest clinics, cardiac imaging division alkmaar, department of nuclear medicine, the netherlands
 
     
   
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