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   assessment of right ventricular sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy: an 123 i-metaiodobenzylguanidine spect/ct study  
   
نویسنده todica andrei ,siebermair johannes ,schiller julia ,zacherl mathias j. ,fendler wolfgang p. ,massberg steffen ,bartenstein peter ,cyran clemens c. ,kääb stefan ,hacker marcus ,wakili reza ,lehner sebastian
منبع journal of nuclear cardiology - 2020 - دوره : 27 - شماره : 6 - صفحه:2402 -2409
چکیده    The purpose of the study was to evaluate a novel approach for the quantification of right ventricular sympathetic dysfunction in patients diagnosed with arvc/d through state-of-the-art functional spect/ct hybrid imaging. sympathetic innervation of the heart was assessed using 123i-mibg-spect/ct in 17 patients diagnosed with arvc according to the modified task force criteria, and in 10 patients diagnosed with idiopathic ventricular fibrillation (ivf). the 123i-mibg-uptake in the left (lv) and right ventricle (rv) was evaluated separately based on anatomic information derived from the ct scan, and compared to the uptake in the mediastinum (m). there was a significant difference in the lv/m ratio between the arvc/d and the ivf groups (3.2 ± 0.5 vs. 3.9 ± 0.8, p = 0.014), with a cut-off value of 3.41 (77% sensitivity, 80% specificity, auc 0.78). there was a highly significant difference in the mean rv/m ratios between both groups (1.6 ± 0.3 vs. 2.0 ± 0.2, p = 0.001), with optimal cut-off for discrimination at 1.86 (88% sensitivity, 90% specificity, auc 0.93). employing state-of-the-art functional spect/ct hybrid imaging, we could reliably assess and quantify right and left ventricular sympathetic innervation. the rv/m ratio was significantly lower in patients diagnosed with arvc/d and provided sensitive and specific discrimination between patients with arvc/d and ivf patients.
کلیدواژه arvc ,mibg ,spect ,ivf ,quantification ,sympathetic innervation
آدرس university of munich, department of nuclear medicine, germany, university duisburg-essen, west-german heart and vascular center essen, department of cardiology and vascular medicine, germany. university of munich, department of cardiology, germany, university of munich, department of nuclear medicine, germany, university of munich, department of nuclear medicine, germany, university of munich, department of nuclear medicine, germany, university of munich, department of cardiology, germany, university of munich, department of nuclear medicine, germany, university of munich, department of clinical radiology, germany, university of munich, department of cardiology, germany, medical university vienna, division of nuclear medicine, department of biomedical imaging and image-guided therapy, austria, university duisburg-essen, west-german heart and vascular center essen, department of cardiology and vascular medicine, germany. university of munich, department of cardiology, germany, university of munich, department of nuclear medicine, germany. ambulatory healthcare center dr. neumaier & colleagues, germany
 
     
   
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