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imaging cardiac innervation in amyloidosis
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نویسنده
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slart riemer h. j. a. ,glaudemans andor w. j. m. ,hazenberg bouke p. c. ,noordzij walter
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منبع
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journal of nuclear cardiology - 2019 - دوره : 26 - شماره : 1 - صفحه:174 -187
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چکیده
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Cardiac amyloidosis is a form of restrictive cardiomyopathy resulting in heart failure and potential risk on arrhythmia, due to amyloid infiltration of the nerve conduction system and the myocardial tissue. the prognosis in this progressive disease is poor, probably due the development of cardiac arrhythmias. early detection of cardiac sympathetic innervation disturbances has become of major clinical interest, because its occurrence and severity limits the choice of treatment. the use of iodine-123 labelled metaiodobenzylguanidine ([i-123]mibg), a chemical modified analogue of norepinephrine, is well established in patients with heart failure and plays an important role in evaluation of sympathetic innervation in cardiac amyloidosis. [i-123]mibg is stored in vesicles in the sympathetic nerve terminals and is not catabolized like norepinephrine. decreased heart-to-mediastinum ratios on late planar images and increased wash-out rates indicate cardiac sympathetic denervation and are associated with poor prognosis. single photon emission computed tomography provides additional information and has advantages for evaluating abnormalities in regional distribution in the myocardium. [i-123]mibg is mainly useful in patients with hereditary and wild-type attr cardiac amyloidosis, not in aa and al amyloidosis. the potential role of positron emission tomography for cardiac sympathetic innervation in amyloidosis has not yet been identified.
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کلیدواژه
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amyloidosis ,sympathetic ,innervation ,mibg
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آدرس
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university medical center groningen, university of groningen, medical imaging center, department of nuclear medicine and molecular imaging (eb50), the netherlands. university of twente, department of biomedical photonic imaging, the netherlands, university medical center groningen, university of groningen, medical imaging center, department of nuclear medicine and molecular imaging (eb50), the netherlands, university medical center groningen, university of groningen, department of rheumatology & clinical immunology, the netherlands, university medical center groningen, university of groningen, medical imaging center, department of nuclear medicine and molecular imaging (eb50), the netherlands
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Authors
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