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effects of cardiac resynchronization therapy on right ventricular function during rest and exercise, as assessed by radionuclide angiography, and on nt-probnp levels
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نویسنده
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valzania cinzia ,biffi mauro ,bonfiglioli rachele ,fallani francesco ,martignani cristian ,diemberger igor ,ziacchi matteo ,frisoni jessica ,tomasi luciana ,fanti stefano ,rapezzi claudio ,boriani giuseppe
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منبع
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journal of nuclear cardiology - 2019 - دوره : 26 - شماره : 1 - صفحه:123 -132
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چکیده
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We carried out this study to investigate mid-term effects of cardiac resynchronization therapy (crt) on right ventricular (rv) function and neurohormonal response, expressed by n-terminal pro-brain natriuretic peptide (nt-probnp), in heart failure patients stratified by baseline rv ejection fraction (rvef). thirty-six patients with nonischemic dilated cardiomyopathy underwent technetium-99m radionuclide angiography with bicycle exercise immediately after crt implantation (during spontaneous rhythm and after crt activation) and 3 months later. plasma nt probnp was assessed before implantation and after 3 months. at baseline, rvef was impaired (≤35%) in 14 patients, preserved (>35%) in 22. at 3 months, rvef improved during rest and exercise (p = .02) in patients with impaired rv function, while remaining unchanged in patients with preserved rv function. rest and exercise rv dyssynchrony decreased in both groups at follow-up (p < .05). a similar mid-term improvement in left ventricular (lv) function and nt-probnp was observed in patients with impaired and preserved rvef. in the former, the decrease in nt-probnp correlated with the improvements both in lv and rv dyssynchrony and functions. crt improve rv performance, during rest and exercise, and neurohormonal response in heart failure patients with nonischemic dilated cardiomyopathy and baseline rv dysfunction. rv dysfunction should not be considered per se a primary criterion for excluding candidacy to crt.
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کلیدواژه
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heart failure ,technetium-99m ,radionuclide angiography
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آدرس
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university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of nuclear medicine, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, university of bologna, s.orsola malpighi hospital, department of nuclear medicine, italy, university of bologna, s.orsola malpighi hospital, department of cardiology, italy, modena university hospital, university of modena and reggio emilia, division of cardiology, italy
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Authors
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