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relationship of non-invasive quantification of myocardial blood flow to arrhythmic events in patients with implantable cardiac defibrillators
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نویسنده
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ghannam michael ,mikhova krasimira ,yun hong jun ,lazarus john j. ,konerman matthew ,saleh ashraf ,weinberg richard l. ,cunnane ryan ,shah ravi v. ,hiller keri m. ,ficaro edward p. ,corbett james r. ,murthy venkatesh l.
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منبع
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journal of nuclear cardiology - 2019 - دوره : 26 - شماره : 2 - صفحه:417 -427
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چکیده
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Ischemia contributes to arrhythmogenesis though its role is incompletely understood. abnormal myocardial perfusion measured by pet imaging predict ventricular arrhythmias (vas) in a high-risk population. patients with implantable cardiac defibrillators who had undergone rubidium-82 cardiac pet imaging were identified. patients were stratified by median mbf and mfr values for analysis. the cox proportional hazards model was used to assess the impact of myocardial perfusion on survival free of vt independent of critical covariates. a total of 159 patients (124 (78%) males, median age 65.9 years, iqr [56.76-72.63]) were followed for 1.43 years iqr [0.83-2.21]. va occurred in 29 patients (23.7%). after adjustment for ejection fraction, age, and sex, impaired stress mbf was associated with an increased risk of va (adjusted hr per ml/min/g 1.52, 95% ci (1.01-2.31), p = 0.04). summed rest and stress scores were not predictive of va. among patients with severe lv dysfunction, stress mbf remained an independent predictor of va (adjusted hr per 1 ml/min/g hr 1.69, 95% ci (1.03-11.36), p = 0.03), while residual ef, summed rest, and summed stress scores were not (p > 0.05). impaired stress myocardial blood flow was associated with less survival free of ventricular arrhythmias.
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کلیدواژه
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myocardial perfusion imaging ,coronary blood flow ,heart failure ,diagnostic and prognostic application
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آدرس
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university of michigan, division of cardiovascular medicine, department of medicine, usa, university of michigan, department of medicine, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa, university of michigan, department of medicine, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa, harvard medical school, massachusetts general hospital, cardiology division, department of medicine, usa, university of michigan, division of nuclear medicine, department of radiology, usa, invia medical imaging solutions, usa. university of michigan, division of nuclear medicine, department of radiology, usa, university of michigan, division of cardiovascular medicine, department of medicine, usa. invia medical imaging solutions, usa, university of michigan, division of cardiovascular medicine, department of medicine, division of nuclear medicine, department of radiology, usa
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Authors
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