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   no need for frame-wise attenuation correction in dynamic rubidium-82 pet for myocardial blood flow quantification  
   
نویسنده dijk j. d. van ,jager p. l. ,ottervanger j. p. ,slump c. h. ,dalen j. a. van
منبع journal of nuclear cardiology - 2019 - دوره : 26 - شماره : 3 - صفحه:738 -745
چکیده    Regadenoson-induced stress causes a repositioning of the heart, myocardial creep, in half of the patients undergoing rubidium-82 (rb-82) positron emission tomography (pet). as a result, misalignment of dynamic pet and computer tomography (ct) occur, possibly affecting ct-based attenuation correction (ac) and thereby pet-based myocardial blood flow (mbf) quantification. our aim was to determine the need for frame-wise pet-ct ac to obtain reliable mbf measurements. 31 out of 64 consecutive patients had myocardial creep during regadenoson-induced stress rb-82 pet-ct and were included. prior to pet image reconstruction, we applied two ac methods; single pet-ct alignment and frame-wise alignment in which pet time-frames with myocardial creep were individually co-registered with ct. the pet-ct misalignment was then quantified and mbfs for the three vascular territories and whole myocardium were calculated and compared between both methods. the magnitude of misalignment due to myocardial creep was 13.8 ± 4.5 mm in caudal-cranial direction, 1.8 ± 2.1 mm in medial-lateral and 2.5 ± 1.8 mm in anterior-posterior direction. frame-wise pet-ct registration did not result in different mbf measurements (p ≥ .07) and the magnitude of misalignment and mbf differences did not correlate (p ≥ .58). there is no need for frame-wise ac in dynamic rb-82 pet for mbf quantification. single alignment seems sufficient in patients with myocardial creep.
کلیدواژه myocardial blood flow ,attenuation correction ,pet-ct registration ,pet rubidium
آدرس isala hospital, department of nuclear medicine, the netherlands, isala hospital, department of nuclear medicine, the netherlands, isala hospital, department of cardiology, the netherlands, university of twente, mira: institute for biomedical technology and technical medicine, the netherlands, isala hospital, department of medical physics, the netherlands
 
     
   
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