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18 f-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques
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نویسنده
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hop h. ,boer s. a. de ,reijrink m. ,kamphuisen p. w. ,borst m. h. de ,pol r. a. ,zeebregts c. j. ,hillebrands j. l. ,slart r. h. j. a. ,boersma h. h. ,doorduin j. ,mulder d. j.
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منبع
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journal of nuclear cardiology - 2019 - دوره : 26 - شماره : 4 - صفحه:1064 -1075
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چکیده
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18f-naf positron emission tomography (pet) targets microcalcifications. we compared in vitro micropet assessed 18f-naf uptake between culprit and non-culprit human carotid plaques. furthermore, we compared 18f-naf uptake with calcification visualized on microcomputed tomography (microct). carotid plaques from stroke patients undergoing surgery were incubated in 18f-naf and scanned using a micropet and a microct scan. the average pet assessed 18f-naf uptake was expressed as percentage of the incubation dose per gram (%inc/g). 18f-naf pet volume of interest (voi) was compared with ct calcification voi. 23 carotid plaques (17 culprit, 6 non-culprit) were included. the average 18f-naf uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %inc/g [iqr 1.98 to 2.81] vs. median 2.35 %inc/g [iqr 1.77 to 3.00], p = 0.916). only a median of 10% (iqr 4 to 25) of ct calcification voi showed increased 18f-naf uptake, while merely a median of 35% (iqr 6 to 42) of 18f-naf pet voi showed calcification on ct. 18f-naf pet represents a different stage in the calcification process than ct. we observed a similar pet assessed 18f-naf uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method be of more value in early atherosclerotic stenosis development.
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کلیدواژه
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18f-sodium fluoride (18f-naf) ,calcification ,pet/ct imaging ,vulnerable atherosclerotic plaque ,carotid artery stenosis
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آدرس
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university medical center groningen, university of groningen, division of vascular medicine, department of internal medicine, the netherlands, university medical center groningen, university of groningen, division of vascular medicine, department of internal medicine, the netherlands, university medical center groningen, university of groningen, division of vascular medicine, department of internal medicine, the netherlands, university medical center groningen, university of groningen, division of vascular medicine, department of internal medicine, the netherlands, university medical center groningen, university of groningen, division of nephrology, department of internal medicine, the netherlands, university medical center groningen, university of groningen, division of vascular surgery, department of surgery, the netherlands, university medical center groningen, university of groningen, division of vascular surgery, department of surgery, the netherlands, university medical center groningen, university of groningen, division of pathology, department of pathology and medical biology, the netherlands, university medical center groningen, university of groningen, department of nuclear medicine and molecular imaging, the netherlands. university of twente, department of biomedical photonic imaging, the netherlands, university medical center groningen, university of groningen, department of clinical pharmacy and pharmacology, department of nuclear medicine and molecular imaging, the netherlands, university medical center groningen, university of groningen, department of nuclear medicine and molecular imaging, the netherlands, university medical center groningen, university of groningen, division of vascular medicine, department of internal medicine, the netherlands
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Authors
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