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   Technetium pyrophosphate uptake in transthyretin cardiac amyloidosis: Associations with echocardiographic disease severity and outcomes  
   
نویسنده Vranian Michael N. ,Sperry Brett W. ,Hanna Mazen ,Hachamovitch Rory ,Ikram Asad ,Brunken Richard C. ,Jaber Wael A.
منبع journal of nuclear cardiology - 2018 - دوره : 25 - شماره : 4 - صفحه:1247 -1256
چکیده    Quantitative uptake of technetium 99 m-pyrophosphate (tcpyp) is sensitive and specific for diagnosing transthyretin cardiac amyloidosis (attr). we sought to examine the association between tcpyp uptake intensity and echocardiographic measures of disease severity and clinical outcomes. a retrospective analysis was performed of 75 patients who underwent tcpyp scintigraphy. planar images were evaluated semiquantitatively and using heart-to-contralateral lung (h/cl) ratio. the associations between h/cl ratio and echocardiographic parameters and outcomes were evaluated using linear regression and cox models, respectively. there were 48 patients diagnosed with attr with mean h/cl ratio 1.58 ± 0.22 (vs 1.08 ± 0.09 if semiquantitative score = 0). the h/cl ratio was not associated with any measured echocardiographic parameter. both semiquantitative uptake grade and h/cl ratio were associated with all-cause mortality (p = 0.009 and 0.007, respectively) and all-cause mortality or heart failure hospitalization (p = 0.001 and 0.020, respectively); however, neither were associated with outcomes when limited to patients with confirmed attr (p = 0.18 and 0.465, respectively). in patients with suspected attr, quantitative and semiquantitative uptake intensity of tcpyp is associated with all-cause mortality as well as all-cause mortality or heart failure hospitalization. however, in those with confirmed attr, there is no association with echocardiographic disease severity or outcomes.
کلیدواژه Transthyretin amyloidosis ,Technetium pyrophosphate ,ATTR ,TcPYP ,Mortality ,Echocardiography
آدرس Cleveland Clinic Foundation, Department of Cardiovascular Medicine, USA, Cleveland Clinic Foundation, Department of Cardiovascular Medicine, USA, Cleveland Clinic Foundation, Department of Cardiovascular Medicine, USA, Cleveland Clinic Foundation, Department of Cardiovascular Medicine, USA, Cleveland Clinic Foundation, Department of Cardiovascular Medicine, USA, Cleveland Clinic Foundation, Department of Nuclear Medicine, USA, Cleveland Clinic Foundation, Department of Cardiovascular Medicine, USA
 
     
   
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