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Molecular imaging of calcific aortic valve disease
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نویسنده
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Jung Jae-Joon ,Jadbabaie Farid ,Sadeghi Mehran M.
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منبع
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journal of nuclear cardiology - 2018 - دوره : 25 - شماره : 4 - صفحه:1148 -1155
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چکیده
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Calcific aortic valve disease (cavd) can progress to symptomatic aortic stenosis in a subset of patients. the severity of aortic stenosis and the extent of valvular calcification can be evaluated readily by echocardiography, ct, and mri using well-established imaging protocols. however, these techniques fail to address optimally other important aspects of cavd, including the propensity for disease progression, risk of complications in asymptomatic patients, and the effect of therapeutic interventions on valvular biology. these gaps be addressed by molecular imaging targeted at key biological processes such as inflammation, remodeling, and calcification that mediate the development and progression of cavd. in this review, recent advances in valvular molecular imaging, including 18f-fluorodeoxyglucose (fdg) and 18f-sodium fluoride (naf) pet, and matrix metalloproteinase-targeted spect imaging in the preclinical and clinical settings are presented and discussed.
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کلیدواژه
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Aortic stenosis ,aortic valve ,molecular imaging ,matrix metalloproteinases ,FDG ,sodium fluoride
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آدرس
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Yale School of Medicine, Cardiovascular Molecular Imaging Laboratory, USA. Yale Cardiovascular Research Center, USA, Yale School of Medicine, Cardiovascular Molecular Imaging Laboratory, USA. Veterans Affairs Connecticut Healthcare System, USA, Yale School of Medicine, Cardiovascular Molecular Imaging Laboratory, USA. Veterans Affairs Connecticut Healthcare System, USA. Yale Cardiovascular Research Center, USA
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Authors
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