>
Fa   |   Ar   |   En
   Assessment of late anthracycline-induced cardiotoxicity by 123 I- m IBG cardiac scintigraphy in patients treated during childhood and adolescence  
   
نویسنده Santos Marcelo José dos ,Rocha Euclides Timóteo da ,Verberne Hein J. ,Silva Eduardo Tinois da ,Aragon Davi Casale ,Junior José Soares
منبع journal of nuclear cardiology - 2017 - دوره : 24 - شماره : 1 - صفحه:256 -264
چکیده    The goal of this study was to evaluate late cardiotoxic effects of anthracyclines (atc) by evaluating cardiac sympathetic activity in a cohort of asymptomatic patients previously treated with atc for childhood cancers. we studied 89 asymptomatic patients previously treated with atc with a normal echocardiogram (49 men and 40 women) and a control group of 40 healthy individuals (26 men and 14 women). both groups underwent planar myocardial 123i-meta-iodobenzylguanidine scintigraphy (123i-mibg). from these images, the early and late heart-to-mediastinum (h/m) ratio and washout rate (wr) were assessed. the mean survival at the time of the 123i-mibg scintigraphy was 5.3 ± 3.4 years. patients treated with atc had a lower but clinical normal left ventricular ejection fraction (lvef) compared to controls (60.44 ± 6.5 vs 64.1 ± 6.0%, p < 0.01). both the late h/m ratio and wr were not able to discriminate atc treated patients from controls. the cumulative atc dose was the only independent predictor of the lvef, explaining approximately 12% of the variation in lvef (p = 0.01). although the pathophysiology behind atc cardiotoxicity is most likely multifactorial, myocardial sympathetic activity is not associated with a reduction in lvef 5-years after completion of chemotherapy.
کلیدواژه Cardiac sympathetic activity ,123I-mIBG ,left ventricular function ,anthracycline
آدرس Barretos Cancer Hospital, Department of Nuclear Medicine, Brazil, Barretos Cancer Hospital, Department of Nuclear Medicine, Brazil, University of Amsterdam, Department of Nuclear Medicine, The Netherlands, ISTRAD – Institute of Security and Technology on Radiation, Brazil, University of São Paulo, Department of Pediatrics, Brazil, University of São Paulo, Brazil
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved