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Myocardial 123 I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations
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نویسنده
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Rosa Anna De ,Pellegrino Teresa ,Pappatà Sabina ,Pellecchia Maria Teresa ,Peluso Silvio ,Saccà Francesco ,Barone Paolo ,Cuocolo Alberto ,Michele Giuseppe De
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منبع
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journal of nuclear cardiology - 2017 - دوره : 24 - شماره : 1 - صفحه:103 -107
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چکیده
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Park2 is an autosomal recessive parkinsonism caused by parkin gene mutations. several parkinson’s disease (pd) cases harbor single parkin mutations, raising a debate about the pathogenic meaning of heterozygous mutations. here, we evaluate cardiac autonomic innervation in patients with either two or one parkin mutations compared to patients with idiopathic pd (ipd). myocardial 123i-metaiodobenzylguanidine (mibg) scintigraphy was performed in six pd patients with single parkin mutations (het), four with two mutations (park2), and eight with ipd. in comparison to control group, ipd patients showed lower early and late heart-to-mediastinum (h/m) ratios and higher washout rates, whereas het patients had only lower early h/m ratio, and park2 patients were not different for any parameter. at individual level, mibg findings were abnormal in 7/8 ipd, in 4/6 het and in 1/4 park2 patients. preserved cardiac 123i-mibg uptake confirms that park2 pathogenic mechanism, at least partially, differs from that responsible for ipd. het subjects show intermediate findings, suggesting possible heterogeneity.
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کلیدواژه
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123I-metaiodobenzylguanidine myocardial scintigraphy ,Parkinson’s Disease ,parkin gene
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آدرس
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Federico II University, Department of Neurosciences and Reproductive and Odontostomatological Sciences, Italy, Institute of Biostructure and Bioimaging, Italy, Institute of Biostructure and Bioimaging, Italy, University of Salerno-CEMAND, Italy, Federico II University, Department of Neurosciences and Reproductive and Odontostomatological Sciences, Italy, Federico II University, Department of Neurosciences and Reproductive and Odontostomatological Sciences, Italy, University of Salerno-CEMAND, Italy, Federico II University, Department of Advanced Biomedical Sciences, Italy, Federico II University, Department of Neurosciences and Reproductive and Odontostomatological Sciences, Italy. Institute of Biostructure and Bioimaging, Italy
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Authors
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