>
Fa   |   Ar   |   En
   Right ventricular dyssynchrony in pulmonary hypertension: Phase analysis using FDG-PET imaging  
   
نویسنده Wang Lei ,Zhou Weihua ,Liang Yu ,Yang Yong ,Garcia Ernest V. ,Chen Ji ,Fang Wei
منبع journal of nuclear cardiology - 2017 - دوره : 24 - شماره : 1 - صفحه:69 -78
چکیده    Right ventricular (rv) performance in patients of pulmonary hypertension (ph) requires optimal assessment. the objective of this study is to develop phase analysis using 18f-fluorodeoxyglucose positron emission tomography (fdg-pet) imaging as a feasible tool for evaluation of rv dyssynchrony in ph. fifty-four ph patients with well-characterized hemodynamic parameters were enrolled. all subjects performed fdg-pet imaging for rv phase analysis and rv function evaluation. two-dimensional echocardiography with speckle tracking analysis was conducted to obtain rv time to peak systolic strain (psst) as a comparison. the median contraction delay difference between rv middle free wall and septum measured by pet phase analysis (rvpdpet) was 20.12° (interquartile range, 4.99°-30.10°). the median difference of psst between rv middle free wall and middle septal wall (rvpdecho) measured by echocardiography was 43.98° (interquartile range, 6.25°-72.00°). rvpdpet was well correlated with rvpdecho (r = 0.685, p < .001). rv phase standard deviation (rvsd) and histogram bandwidth (rvbw) derived from pet phase histogram were significantly correlated with cardiac index, rv ejection fraction, 6-minute walking distance, and serum n-terminal pro b-type natriuretic peptide (nt-probnp) (rvsd: r = −0.532, p < .001; r = −0.551, p < .001; r = −0.544, p < .001; r = 0.404, p < .01; respectively, rvbw: r = −0.492, p < .001; r = −0.466, p < .001; r = −0.544, p < .001; r = 0.349, p = .01, respectively), while there were no significant correlations between rvsd and rvbw with hemodynamic parameters (right atrial pressure, right ventricular systolic pressure, right ventricular end-diastolic pressure, mean pulmonary artery pressure, and total pulmonary resistance). contraction delays between rv free wall and septum in ph measured by phase analysis and speckle tracking echocardiography were well correlated. rv dyssynchrony measured by phase analysis of fdg-pet was significantly related to rv dysfunction. phase analysis of fdg-pet is feasible to evaluate rv mechanical dyssynchrony in patients of ph.
کلیدواژه Fluorodeoxyglucose ,pulmonary hypertension ,right ventricle ,dyssynchrony ,phase analysis
آدرس Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Nuclear Medicine, China. Imperial College London, UK, University of Southern Mississippi, USA, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Echocardiography, China, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Nuclear Medicine, China, Emory University School of Medicine, Department of Radiology, USA, Emory University School of Medicine, Department of Radiology, USA, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Nuclear Medicine, China
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved