Accuracy of myocardial perfusion imaging in detecting multivessel coronary artery disease: A cardiac CZT study

Myocardial perfusion imaging (mpi) performed on traditional single-photon emission computed-tomography cameras has been shown to have a sub-optimal accuracy in detecting multivessel coronary artery disease (cad). six-hundred and ninety-five patients were submitted to mpi on a novel cadmium-zinc-telluride (czt) camera and coronary angiography. a coronary stenosis >70% was considered obstructive. in every patient, the summed stress score (sss) was computed. moreover, the regional stress scores were also calculated for every coronary territory. four-hundred and forty-one patients had obstructive cad in one (28%), two (19%), or three (17%) vessels. at per-patient analysis, the sss showed a significant accuracy in detecting obstructive cad (auc 0.87, p < .001). specifically, its accuracy was maintained also in patients with double (auc 0.83; p < .001) or triple-vessels disease (auc 0.79, p < .001), where czt was able to correctly identify cad extent in 64% of patients. on a per-vessel basis, czt confirmed its high accuracy in detecting obstructive cad (auc 0.88, p < .001), independently from the involved coronary vessel. mpi performed on a czt camera is highly accurate in detecting obstructive cad, independently from the coronary artery involved and the overall disease burden.