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   The EXERRT trial: “EXErcise to Regadenoson in Recovery Trial”: A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol  
   
نویسنده Thomas Gregory S. ,Cullom S. James ,Kitt Therese M. ,Feaheny Kathleen M. ,Ananthasubramaniam Karthikeyan ,Gropler Robert J. ,Jain Diwakar ,Thompson Randall C.
منبع journal of nuclear cardiology - 2017 - دوره : 24 - شماره : 3 - صفحه:788 -802
چکیده    This study assessed the non-inferiority and safety of regadenoson administration during recovery from inadequate exercise compared with administration without exercise. patients unable to achieve adequate exercise stress were randomized to regadenoson 0.4 mg either during recovery (ex-reg) or 1 hour after inadequate exercise (regadenoson) (mpi1). all patients also underwent non-exercise regadenoson mpi 1-14 days later (mpi2). the number of segments with reversible perfusion defects (rpds) detected using single photon emission computerized tomography imaging was categorized. the primary analysis evaluated the majority agreement rate between ex-reg and regadenoson groups. 1,147 patients were randomized. the lower bound of the 95% confidence interval of the difference in agreement rates (−6%) was above the −7.5% non-inferiority margin, demonstrating non-inferiority of ex-reg to regadenoson. adverse events were numerically less with ex-reg (mpi1). in the ex-reg group, one patient developed an acute coronary syndrome and another had a myocardial infarction following regadenoson after exercise. upon review, both had electrocardiographic changes consistent with ischemia prior to regadenoson. administering regadenoson during recovery from inadequate exercise results in comparable categorization of segments with rpds and with careful monitoring appears to be well tolerated in patients without signs/symptoms of ischemia during exercise and recovery.
کلیدواژه Exercise ,pharmacologic stress ,vasodilator stress ,myocardial perfusion imaging ,regadenoson
آدرس MemorialCare Heart & Vascular Institute, USA. University of California, USA, AdaptivePharma, USA. University of Missouri, USA, Astellas Pharma Global Development, Inc., USA, Astellas Pharma Global Development, Inc., USA, Henry Ford Hospital, Department of Internal Medicine, USA, Washington University School of Medicine, Division of Radiological Sciences, USA, Westchester Medical Center, Cardiovascular Nuclear Imaging Laboratory, USA, Saint Luke’s Mid America Heart Institute, USA. University of Missouri-Kansas City, USA
 
     
   
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