PET-CT evaluation of amyloid systemic involvement with [ 18 F]-florbetaben in patient with proved cardiac amyloidosis: a case report

One of the most frequent disorders which lead to cardiac amyloidosis is transthyretin-related amyloidosis (attr). some pet radio-pharmaceuticals for the detection of beta-amyloid deposits within the brain have shown to be able to detect also cardiac amyloid deposits. we present a case of a man with attr studied with [18f]-florbetaben pet-ct. total-body scan showed a moderate uptake in the bone marrow, especially in correspondence of the vertebral column, while no significant myocardial uptake was present. cardiac-focused scans showed low mean cardiac suv values confirming the absence of significant myocardial uptake. brain scan showed a significant cortical brain uptake of the radio-pharmaceutical more evident in correspondence of frontal and temporal lobes. distinct subtypes of amyloidosis show different uptake of the radiotracer. brain amyloid deposition in the presence of a systemic disease could not be caused by the same amyloid precursor.