|
|
Does diastolic dysfunction precede systolic dysfunction in trastuzumab-induced cardiotoxicity? Assessment with multigated radionuclide angiography (MUGA)
|
|
|
|
|
نویسنده
|
Reuvekamp E. J. ,Bulten B. F. ,Nieuwenhuis A. A. ,Meekes M. R. A. ,Haan A. F. J. de ,Tol J. ,Maas A. H. E. M. ,Elias-Smale S. E. ,Geus-Oei L. F. de
|
منبع
|
journal of nuclear cardiology - 2016 - دوره : 23 - شماره : 4 - صفحه:824 -832
|
چکیده
|
Trastuzumab is successfully used for the treatment of her2-positive breast cancer. because of its association with cardiotoxicity, lvef is monitored by muga, though this is a relatively late measure of cardiac function. diastolic dysfunction (dd) is believed to be an early predictor of cardiac impairment. we evaluate the merit of muga-derived diastolic function parameters in the early detection of trastuzumab-induced cardiotoxicity (tic). 77 trastuzumab-treated patients with normal baseline systolic and diastolic function were retrospectively selected (n = 77). all serial muga examinations were re-analyzed for systolic and diastolic function parameters. 36 patients (47%) developed sd and 45 patients (58%) dd during treatment. both systolic and diastolic parameters significantly decreased. of the patients with sd, 24 (67%) also developed dd. dd developed prior to systolic impairment in 54% of cases, in 42% vice versa, while time to occurrence did not differ significantly (p = .52). this also applied to the subgroup of advanced stage breast cancer patients (p = .1). trastzumab-induced sd and dd can be detected by muga. an impairment of muga-derived diastolic parameters does not occur prior to sd and therefore cannot be used as earlier predictors of tic.
|
کلیدواژه
|
Breast cancer ,monoclonal antibodies ,cardiotoxicity ,radionuclide imaging ,diastolic function
|
آدرس
|
Department of Radiology and Nuclear Medicine, Radboudumc, The Netherlands, University of Twente, Biomedical Photonic Imaging Group, The Netherlands, Department of Radiology and Nuclear Medicine, Radboudumc, The Netherlands, Department of Radiology and Nuclear Medicine, Radboudumc, The Netherlands, Department for Health Evidence, Radboudumc, The Netherlands, Department of Medical Oncology, Radboudumc, The Netherlands, Department of Cardiology, Radboudumc, The Netherlands, Department of Cardiology, Radboudumc, The Netherlands, University of Twente, Biomedical Photonic Imaging Group, The Netherlands. Leiden University Medical Centre, Department of Radiology, The Netherlands
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|