The outcome of surgically resected anaplastic astrocytoma and glioblastoma: Results of single center retrospective study [Cerrahi çi{dotless}kari{dotless}m yapi{dotless}lan anaplastik astrositomlari{dotless}n ve glioblastomlari{dotless}n saǧkali{dotless}m analizi: Tek merkezli retrospektif çali{dotless}şma sonuçlari{dotless}]

Objective: anaplastic astrocytomas and glioblastomas are the most common primary cerebral neoplasms in adults. unfortunately,despite newly developed therapies and surgical techniques,the clinical course of anaplastic astrocytomas and glioblastomas is very rapid and almost always they have miserable prognosis. we report the outcome of surgically resectioned anaplastic astrocytomas and glioblastomas in our clinic. methods: we retrospectively analyzed the records including age of diagnosis,preoperative karnofsky performance score,survival period,histological grade of the tumor; extend of surgical resection,and postoperative treatment status of all anaplastic astrocytomas and glioblastomas operated. the patients (n=164) who died in this period have been included in this study. results: overall survival of the patients with anaplastic astrocytomas was 25.4 months; and 8.3 months for glioblastomas; six months progression free survival was 42.5% for patients with anaplastic astrocytomas; and 14.5% for those with glioblastomas. six months and 1 year survival rates of gross total removal plus near total removal group were 76.8% and 45.8% respectively. six months and 1 year survival rates of subtotal removal group was 55.6% and 22.2% respectively. conclusion: as expected,overall survival tends to be longer for patients with anaplastic astrocytomas. overall survival and life expectation were longer for patients with six months progression free survival. preoperative high karnofsky performance score and younger age at the time of diagnosis were associated with good prognosis. gross total removal plus near total removal group had higher survival rates compared with subtotal removal group and biopsy groups.