Adie's tonic pupil and anti-ganglioside igG antibodies [Adie'nin tonik pupillasi{dotless}nda anti-gangliozid igG antikorlari{dotless}]

Objective: the presence of anti-ganglioside igg antibodies has been reported in the guillain- barre syndrome (gbs) and the miller-fisher syndrome (mfs). adie's tonic pupil (atp) is similar to gbs and its variants with the symmetric decrease in reflexes and the mydriasis that is an indicator of a parasympathetic disorder but the relationship between atp and antiganglioside antibodies is unknown. our aim in this study was to investigate the presence of anti-ganglioside igg antibodies in patients with atp. patients and method: the study group consisted of a total of 20 persons with 10 patients and 10 control subjects. the control group consisted of healthy persons who did not have any problems that could influence the immune system. a neuro-ophthalmological examination was performed in all patients and the presence of anti-ganglioside antibodies in the serum was investigated. results: serum anti-ganglioside antibodies were negative in the 3 patients included in the study according to the review of old patient charts. anti-gd1b,anti-gt1b and anti-gm3 antibodies were positive in 2 and anti-gm3 antibodies in 1 of the 7 patients included in the study after a new diagnosis was made. anti-ganglioside antibodies were negative in all control group subjects. conclusion: at least one of the anti-ganglioside antibodies was found to be positive in approximately half of the atp patients in the acute stage (3 of the 7 acute or subacute stage atp patients). these results indicate that anti-ganglioside antibodies may play a role in atp development.