The Synergistic effect of fotemustine and genistein on expressions of p53,EGFR and COX-2 genes in human glioblastoma multiforme cell line [Fotemustin ve Genisteinin Glioblastom Multiforme Hücre Hatti{dotless}nda p53,EGFR ve COX-2 Genlerinin Ekspresyonlari{dotless} Üzerine Sinerjistik Etkisi]

Gbm is the most common primary malignant neoplasm of the central nervous system in adults. fotemustine (ftm) is a cytotoxic alkylating agent and a lipophilic chloroethylnitrosourea derivative. its mechanism of action consists mainly in inducing dna strand breaks and cross-linking. genistein,one of the soy-derived isoflavones,exerts its anticancer properties via several mechanisms,including inhibition of tyrosine phosphorylation,weak estrogenic and anti-estrogenic properties,as an antioxidant,inhibition of topoisomerase ii,inhibition of angiogenesis,and induction of cell differentiation in a number of human tumors. we aimed to investigate the anti-proliferative synergistic effect of genistein with fotemustine on human glioblastoma multiforme u87-mg cells. this study was also designed to answer the following question: do the p53,egfr,cox-2 genes' expression patterns differ in treatment of these both drugs alone and in combination?